May 1, 2003 · It is essential that physicians know how to evaluate and optimally manage patients with hypercalcemia, because treatment and prognosis vary according to the underlying disorder. The …

Bhangu JS, Selberherr A, Brammen L, et al. Efficacy of calcium excretion and calcium/creatinine clearance ratio in the differential diagnosis of familial hypocalciuric hypercalcemia and primary …

Mar 19, 2025 · Among all causes of hypercalcemia, primary hyperparathyroidism and malignancy are the most common, accounting for greater than 90 percent of cases [1]. Therefore, the diagnostic …

Nov 20, 2025 · Hypercalcemia typically causes severe volume depletion (e.g., 3-6 liters) due to enhanced fluid excretion by the kidneys and reduced oral intake. This may cause renal insufficiency, …

This practice consensus statement is based on majority opinion of the Hypercalcemia workgroup at the University of Texas MD Anderson Cancer Center for the patient population.

Dec 5, 2025 · Mild cases of hypercalcemia can be asymptomatic and are more often diagnosed incidentally from routine blood tests. Because calcium metabolism normally is tightly controlled by …

2 days ago · Hypercalcemia Work-Up: Step-by-Step Diagnostic Algorithm Measure serum calcium (corrected for albumin or ionized), intact parathyroid hormone (PTH), basic metabolic panel, …

FHH presents with high plasma calcium but low urinary calcium, with a high or normal PTH. A spot urine calcium excretion ≤ 22 μmol/l is likely to signify FHH when hypercalcaemia is present.

Background: Hypercalcemia is a serum calcium level above the upper limit of normal. While reference ranges vary by laboratory, it is usually defined as ionized fraction of calcium > 5.6 mg/dL (1.4 …

This algorithm provides an approach for the differential diagnosis of hyperparathyroidism/hypercalcemia.