Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Polish and US researchers have found a way to stop a destructive form of cell death after it has already begun.

Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against the infection of bacterial and viral pathogens. Pyroptosis is executed by gasdermin, ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Chemotherapy administered to cancer patients has a variety of adverse side effects such as tissue damage, reduced immunity, and weight loss. Preventing these unwanted side effects could improve the ...

Cancer immunotherapy methods turn up the heat on cancer. Some methods effectively strip cancer cells of their immune-system-deceiving disguises. Other methods subject cancer cells to the targeted ...

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present. Immune cells ...

In a twist that complicates the future of treatment for severe liver disease, scientists have discovered that blocking a key inflammatory protein in the liver may save one organ while damaging others.