Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance.

To stay healthy, our cells rely on a self-cleaning mechanism that removes defective or unnecessary components. This process, ...

Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with ...

Researchers uncover a hidden nanoscale mechanism critical for Met receptor activation, providing a new blueprint for targeted ...

Chronic diseases such as type 2 diabetes and inflammatory disorders are a major cause of disease burden and deaths around the world, but their treatment has proven difficult because there may not be ...

RNA-binding proteins use a dual binding mechanism involving zinc finger (ZnF) domains and intrinsically disordered regions (IDR), reports a new study from Institute of Science Tokyo, Japan. Using ...

Researchers identify two key proteins that allow chandelier cells to connect with excitatory neurons. This "handshake" regulates brain signals and, when disrupted, may lead to epilepsy or autism.

The last time I wrote about Recursion Pharmaceuticals, Inc. (RXRX), it was in a Seeking Alpha article entitled “Recursion: Path Forward For REC-994 Remains Despite Mixed Response.” In the article, I ...

A deep dive into the scientific shift toward multi-target obesity therapeutics and its implications for metabolic health and ...

The concept of immunotherapy or boosting the body’s immune system to target tumors was first practically applied in the early ...