Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against the infection of bacterial and viral pathogens. Pyroptosis is executed by gasdermin, ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Chemotherapy administered to cancer patients has a variety of adverse side effects such as tissue damage, reduced immunity, and weight loss. Preventing these unwanted side effects could improve the ...

Pyroptosis is a unique immunogenic form of cell death dependent on inflammasome activation, provoked when pattern recognition receptors (PRRs) sense microbial infection or cellular stress. Caspase-1, ...

Cancer immunotherapy methods turn up the heat on cancer. Some methods effectively strip cancer cells of their immune-system-deceiving disguises. Other methods subject cancer cells to the targeted ...

A new study published in the journal Nature in March 2020 reports the discovery of a new approach to cancer immunotherapy, which could be useful in many more cancers than at present. Immune cells ...

In a twist that complicates the future of treatment for severe liver disease, scientists have discovered that blocking a key inflammatory protein in the liver may save one organ while damaging others.