One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Chromosomes are thread-like structures that carry a cell's ...

Small, cancer-associated DNA circles "hitchhike" on chromosomes during cell division to spread efficiently to daughter cells by co-opting a process used to maintain cellular identity through ...

Human DNA, which is approximately two meters in length, is organized into a compact, thread-like structure known as the chromatin, so it could fit into the nucleus, a tiny sphere that’s only about six ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

Cancer cells with a cell nucleus that is easily deformed are more sensitive to drugs that damage DNA. These are the findings of a new study by researchers at Linköping University in Sweden. The ...

Genes are segments of DNA (deoxyribonucleic acid) that are located inside every human cell. The DNA inside each cell is tightly coiled in structures called chromosomes. Each chromosome contains a ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell’s nucleus. The ...

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Genomes contain the complete library of information required to build and maintain a living organism — the figurative blueprints of life. In eukaryotes, genomes are stored in the nuclei, where they ...